Design, synthesis and biological activities of 5Hdibenzo[ b,f]azepine-5-carboxamide derivatives; Targeted hippocampal trypsin inhibition as a novel approach to treat epileptogenesis

Purpose: To synthesize anticonvulsant drug derivatives that target protease-activated receptor generated epileptic seizures.Method: Varieties of carbamazepine-based Schiff bases were designed with different aldehydes and ketones, evaluated for in silico computer-aided design prediction absorption, distribution, metabolism excretion (ADME), potential targets. The resultant compounds synthesized characterized by various spectroscopic techniques, including FTIR, 1H-NMR 13CNMR, analysis. Thereafter, they screened antimicrobial, antioxidant potential.Results: Prominent anti-protease was shown C7 C3 the order activity > C5 C2 C6 C4 C1 (p < 0.05). comparable standard drug; C3, C4, C8 had mild while showed least activity. exhibited significant 0.05) (rank order: C2) antimicrobial against S.aureus B. bronchiseptica C7).Conclusion: Synthesized retained their antitrypsin activity, unlike mother moiety, i.e., carbamazepine. additional antibacterial effectively treats neurological disorders associated bacterial infections.